2-Hydroxy-5-Hydroxymethyl Pyridine

2-Hydroxy-5-Hydroxymethyl Pyridine - Names and Identifiers

Name	5-(hydroxymethyl) pyridin-2(1H)-one
Synonyms	2-Hydroxy-5-pyridine methanol 5-Hydroxymethyl-1H-pyridin-2-one 2-Hydroxy-5-Hydroxymethyl Pyridine 5-(HydroxyMethyl)-2(1H)-pyridinone 5-(hydroxymethyl)pyridin-2(1H)-one 5-(hydroxymethyl) pyridin-2(1H)-one 2(1H)-Pyridinone, 5-(hydroxyMethyl)- 2(1H)-Pyridinone,5-(hydroxymethyl)-(9CI) 5-(hydroxyMethyl)-1,2-dihydropyridin-2-one 2-HYDROXY-5-PYRIDINEMETHANOL(2-HYDROXY-5-HYDROXYMETHYLPYRIDINE)
CAS	109205-68-7
InChI	InChI=1/C6H7NO2/c8-4-5-1-2-6(9)7-3-5/h1-3,8H,4H2,(H,7,9)

2-Hydroxy-5-Hydroxymethyl Pyridine - Physico-chemical Properties

Molecular Formula	C6H7NO2
Molar Mass	125.13
Density	1.225±0.06 g/cm3(Predicted)
Boling Point	428.0±27.0 °C(Predicted)
Flash Point	212.7°C
Vapor Presure	4.03E-09mmHg at 25°C
pKa	11.56±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.538

2-Hydroxy-5-Hydroxymethyl Pyridine - Introduction

2-hydroxy-5-hydroxymethylpyridine (pyridine) is an organic compound with the chemical formula C6H7NO2.

Nature:
-Appearance: 2-Hydroxy-5-hydroxymethylpyridine is a colorless or pale yellow liquid.
-Solubility: Soluble in water and alcohol solvents.
-Melting point and boiling point: the melting point is 14-18 degrees Celsius, and the boiling point is 196-197 degrees Celsius.

Use:
-2-Hydroxy-5-hydroxymethylpyridine is widely used as a reagent in organic synthesis. It can be used as a catalyst for esterification reactions, catalyzing the reaction of alcohols with acids to form esters.
-The compound can also be used to prepare pharmaceutical intermediates and pharmaceuticals.

Preparation Method:
-2-Hydroxy-5-hydroxymethylpyridine can be prepared by a Kotropos-type condensation reaction of 2-hydroxy-5-hydroxymethylpyridine aldehyde (aldehyde). The reaction needs to use sodium cyanide or hydrogen cyanide to treat 1-methyl -2-pyridine formaldehyde, generate 2-hydroxyl -5-methyl pyridine alcohol aldehyde, and then through catalytic hydrogenation reaction to obtain 2-hydroxyl -5-hydroxymethyl pyridine.

Safety Information:
-2-hydroxy-5-hydroxymethylpyridine has low toxicity, but it is still necessary to avoid inhalation or contact with skin, eyes and other parts.
-During use, good ventilation should be taken and appropriate personal protective equipment should be worn, such as chemical protective glasses and gloves.
-Store in an airtight container, away from ignition and oxidizing agents.

Last Update：2024-04-09 02:00:41